Lipoxygenases in the Cardiovascular System
نویسندگان
چکیده
منابع مشابه
Lipoxygenases in the cardiovascular system.
Lipoxygenases (LOXs) are nonheme iron-containing enzymes that catalyze dioxygenation of free or esterified polyenoic fatty acids to the corresponding hydroperoxides.1 Although LOXs in plants have been known for almost a century, the first mammalian LOXs were not discovered until the mid 1970s.2 In 1984 a 15-LOX activity was described in human atherosclerotic lesions,3 and since then the number ...
متن کاملUpdate on Plant Lipoxygenases Plant Lipoxygenases. Physiological and Molecular Features
Lipoxygenases (LOXs; EC 1.13.11.12) are nonheme iron-containing dioxygenases widely distributed in plants and animals. LOX catalyzes the addition of molecular oxygen to polyunsaturated fatty acids containing a (Z,Z)-1,4-pentadiene system to produce an unsaturated fatty acid hydroperoxide. LOX initiates the synthesis of a group of acyclic or cyclic compounds collectively called oxylipins, which ...
متن کاملRole of lipoxygenases in breast cancer.
The interaction of growth factors such as epidermal growth factor (EGF) with their receptors on breast cancer cells can lead to the hydrolysis of phospholipids and release of fatty acids such as arachidonic acid which can be further metabolized by the lipoxygenase (LO) pathway. Several LO products have been shown to stimulate oncogenes and have mitogenic and chemotactic effects. The 12-LO produ...
متن کاملThe effect of glutaminergic system on cardiovascular regulation of rat
Introduction: The bed nucleus stria terminalis (BST) is a part of the limbic system, which plays a role in regulation of heart beat and blood circulation. It was recently shown that microinjection of L-glutamate in the BST elicits cardiovascular depressive, but the role of glutamate receptor subtypes has not been investigated yet. In this study, the role of glutamate receptor subgroups in regul...
متن کاملEffects of Benzimidazole derivatives on digestive system and cardiovascular system
One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000134763.72053.50